AN EVALUATION OF THE EFFECTS OF SAFFRON SUPPLEMENTATION ON THE ASTHMA CLINICAL SYMPTOMS AND ASTHMA SEVERITY IN PATIENTS WITH MILD AND MODERATE PERSISTENT ALLERGIC ASTHMA: A DOUBLE-BLIND, RANDOMIZED PLACEBO-CONTROLLED TRIAL

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 388

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شناسه ملی سند علمی:

INC15_653

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Background and Aim: Background Asthma is a heterogeneous disease which is usually associated with chronic airway inflammation. Hypothesis The present study was intended to survey the effects of saffron supplementation on blood pressure, lipid profiles, basophils, eosinophils and clinical symptoms in patients with allergic asthma. Study Design our study was a clinical trial. Methods: Methods Subjects (N= 80, 32 women and 48 men, 18–65 years old) with mild and moderate allergic asthma were randomized into two groups: the intervention group who received two capsules of saffron (100mg/d), and the control group who received two capsules of placebo for 8 weeks. Blood pressure, lipid profiles, basophils, eosinophils and clinical symptoms were determined in the patients before and after the intervention. SPSS software (version 16.0) was used for the data analysis. Results: Results Saffron improved clinical symptoms of the patients (i.e., frequency of the shortness of breath during the day and night time, use of salbutamol spray, waking up due to asthma symptoms and activity limitation) in comparison to the placebo (p <0.001). Besides, asthma severity decreased almost significantly in the saffron group (p=0.07). It was also found that saffron, in comparison with the placebo, significantly reduced the systolic and diastolic blood pressure, triglycerides and low density lipoprotein cholesterol. Moreover, eosinophils (p=0.06) and basophils (p=0.05) concentration borderlines significantly reduced in the saffron group. Conclusion: Conclusion Saffron seems to be an effective and safe option to improve clinical symptoms of patients with allergic asthma. Registration ID in IRCT (IRCT2017012132081N2).

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نویسندگان

Marzie Zilaee

Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran