Quality improvement in care of congenital CMV infection

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 362

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شناسه ملی سند علمی:

INHCMED06_029

تاریخ نمایه سازی: 30 آذر 1398

چکیده مقاله:

CYTOMEGAIOVIRUS cmv is adouble stranded enveloped DNA virus that results lifelong infection. EPIDEMIOLOGY -сmy is currently the most common intrauterine infection. -сmy is responsible for congenital infection in0/15 to 2%of newborns, and it is leading cause of deafness and learning disability, infection is more prevalent in underdeveloped countries and among lower socioeconomic group in developed countries, where crowding and poor hygiene ara more common. CMV is present in saliva, urin, genital secretions, breast milk, blood and blood products of infected persons. -primary infection (acute infection) is usually asymptomatic in older infants ,childrens, and adults but may manifest with mononucleosis like symptoms including a prologed fever and a mild hepatitis. MATERNAL CLINICAL MANIFESTATION most women are asymptomatic during either primary or recurent infection. A mononucleosis-like illness may develop in 5% to 10% of women. TRANSPLACENTAL TRANSMISSION is responsible for congenital infection in1%of newboms, and intrauterine fetal death may be more likely. Congenital infection may occur after either a primary or a reactivated infection in mother. Overall, only 5% to 10%of congenital infections are symptomatic and these are more likely after a primary maternal infection, although symptomatic infections have been reported in women with reactivation infections, and reinfection. -Symptomatic infants have a mortality of 20% to30% and two third of survivors may have sequelae. -The 90%of infants with asymptomatic infection at birth also have a 5%to 15% risk of later sequelae. -Even with primary maternal infection during pregnancy, transplacental infection occurs in only 30%to40% of the fetus, and only 10% to 15% of these infected fetus develop symptomatic disease. With recurrent maternal CMV infection during gestation, only 1% to 3% of fetus are infected-Although transmission seems to be increased in the third trimester. The risk of malformations occur during the period of organogenesis.

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