Acute Kidney Injury in neonates

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 348

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شناسه ملی سند علمی:

INHCMED06_030

تاریخ نمایه سازی: 30 آذر 1398

چکیده مقاله:

Aim and background: Acute kidney injury (AKI) is a challenging item in diagnosis and management due to endowment renal physiology in neonates. the aim of this review is to introduce new criteria of neonatal AKI, the marker of diagnosis and classification, the underlying disease, management and outcome. Methods: Literature was searched through pubmed and scholar.google through 2016-2019 to update the new criteria and management of nAKI. Moreover, the Iranian studies about neonatal acute kidney injury was reviewed to find the prevalence , etiology and outcome of neonates. Results: Short definition of nAKI is using rise Serum creatinin from the baseline, or decrease urine output (UOP) in 24 hours. According to Ser and UOP the AKI classified to stage 0 to 3. The prevalence of AKI increased with implication this new classification. The hemodynamic instability due to sepsis, asphyxia, heart failure consist the majority of underlining disease. The new urine biomarkers help to earlier detection of AKI before rising Scr. Identifying high risk neonates in order to close monitoring of Scr and UOP, avoiding of nephrotox drugs and judies implication of fluid therapy help to prevent naki. In premature newborn with asphyxia single dose of theophylin reduce the possibility of AKI. Neonates with AKI are prone to higher mortality and at risk of chronic kidney disease in later of life. Longtime follow up is recommended. In conclusion: Consider the rise, peak , and nadir Ser to identify AKI, detect-the majority at risk , evaluate clinical , relevant laboratory tests, and do appropriate management and consilder long term follow up

نویسندگان

Nakysa Hooman

Prof Pedaitric Nephrology Aliasghar Clinical Research Development Center (AACRDC), Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran