Personalization of treatment and Investigation of Tumor Response Prediction to Simultaneous Neoadjuvant Chemo-radiation Therapy Using quantitative features derived from MRI images in colorectal Cancer Patients

Background: Despite many advances in the field of diagnosis and treatment of colorectal cancer has been established as the leading cause of deaths from cancer. This type of cancer is the third cause of cancer and second leading cause of cancer death in developed countries so that 750,000 new cases of colorectal cancer and 350,000 cancer deaths in developing countries in 2015 are estimated. Personalized treatment and proper treatment in terms of characteristics and circumstances of each individual can make a big difference in improving the health of each patient. Needed to personalize the therapy and treatment regimens to achieve acceptable treatment is a quantitative information. The aim of this study was to extract quantitative information from tumor volume of MRI images in patients with colorectal cancer and determine the relationship between extracted image features and patients response to therapy.Material and Methods: In this study, 54 patients with advanced colorectal cancer were recruited. All patients before initiating Simultaneous Neoadjuvant Chemo-radiation Therapy were imaged in the pelvic area with 1.5 tesla MRI system. Then, under the supervision of oncology patients treated with the standard treatment regimen of Simultaneous Neoadjuvant Chemo-radiation Therapy and 2 weeks after completion of treatment the tumor pathologic samples have been analyzed in the pathology lab for invasive response evaluation. In the final phase features extracted from images of the tumor volume and the relationship between response to treatment and features extracted from MRI images is studied.Conclusions: features extracted from the target volume images accurately predict the response to treatment in patients with colorectal cancer and compared to the previous factors such as tumor size and length are more accurate.

کلیدواژه ها:

personalized treatment ، Response to treatment ، Simultaneous Neoadjuvant Chemo-radiation Therapy ، Colorectal