Genotyping and expression study of NRG1 in schizophrenic patients have presented biomarkers for negative symptoms

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 388

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شناسه ملی سند علمی:

IPMCMED01_133

تاریخ نمایه سازی: 23 آذر 1397

چکیده مقاله:

Schizophrenia (SCZ) is a complex psychiatric disorder with no clarified etiology or biological diagnosis. Most common symptoms of schizophrenia are positive, negative and cognitive. Neurodevelopmental deficiencies have been suggested as one of the possible reasons of schizophrenia. Neuregulin1 (NRG1) gene-located at 8p12- is an epidermal growth factor which is essential for normal development of central nervous system. NRG1 has several isoforms that could be grouped in six type based on their functions. Type I, II and III of NRG1 are expressed in excitatory and inhibitory neurons, as well as astrocytes and are involved in regulation of neuronal activity.Prevalence of 13 most common single nucleotide polymorphisms of NRG1 in psychosis along with mRNA level of types I, II and III in this gene were studied in blood samples of 190 Iranian schizophrenic patients and 150 non-psychiatric subjects using quantitative Real time PCR. Also positive and negative symptom scale (PANSS) and brief psychiatric rating scale (BPRS) from patients and Wechsler Adult Intelligence Scale (WAISE) from all subjects were obtained.Presence of rs2954041, rs3924999 and rs6994992 were significantly associated (pResults have confirmed role of NRG1 in schizophrenia. Findings showed down regulation of types I, II and III of NRG1 in schizophrenia which were significantly related to lack of emotional and executive functions and could be a marker of low neural activity in schizophrenic brain. In addition rs3924999 have presented as marker for down expression of NRG1 and a potential peripheral marker for negative symptoms of schizophrenia.

کلیدواژه ها:

NRG1 - schizophrenia - gene expression - rs3924999

نویسندگان

Zahra Sadat Hosseini

faculty of biological science,kharazmi university,karaj,iran

Mohammad Tahmaseb

faculty of biological science,kharazmi university,karaj,iran

Sahel Hemmati

Pediatric neurohabilitation research center, social welfare and rehabilitation sciences university, Tehran, Iran

Arvin Haghighatfard

Department of biology, Tehran North branch, Islamic Azad University, Tehran, Iran