The effect of personal medicine with analysis epigenetics biomarkers and changes of miRNA expression profile in diagnosis and treatment of prostate cancer

One of the incident cancer in men is prostate cancer, which in spite of large study about diagnosis and treatment of this cancer, this is one of main reason of death in the men. Prostate cancer like other cancer, have different environmental and genetic reasons that the analysis of genetic reason available the field of study about personal medicine diagnosis and treatment of this cancer. Personal medicine is advanced branch of medicine that with use of the most appropriate diagnostic biomarkers, determine the kind and the best treatment for person with cancer. The study of expression changes of biomarkers such as microRNAs (miRNAs), is one of the method in targeted diagnostic and treatment. In this study a table of microRNAs expression changes and genes that have effect in diagnosis and treatment of prostate cancer, with study in relevant article and search in science direct, PubMed and google scholar get available. In addition of genetic changes, mechanism of epigenetics such as DNA methylation, Histone modifications and change in miRNAs expression, have effect in the diagnosis and treatment of prostate cancer. MicroRNAs after the transcription play their regulatory role, and because of stability and specificity expression in any tissue, they are used as the best biomarkers for prognosis factor and treatment of cancers, also prostate cancer.

کلیدواژه ها:

Personal medicine ، Prostate cancer ، microRNA ، Epigenetics biomarkers