Survey of reaction between arylglyoxal derivatives, phenyl hydrazine, in the presence Meldrum s acid as catalyst

The pyrazole cores are one of the most important heterocycles compound, they have been attention in recently years due can be found in many pharmaceutical field (suchas the anti-anxiety, antipyretic, analgesic and anti-inflammatory drugs) [1]. Recently, some were reported to have non-nucleoside HIV-1 reverse transcriptase inhibitory activity [2]. Herein, we have developed a highly efficient, catalyst-free and green method for the one-pot three-component synthesis of (Z)-2-(aryl)-2-oxo-N ,N - diphenylacetohydrazonohydrazide derivatives 4 from Meldrum s acid as catalyst 1, arylglyoxal derivatives 2 and phenyl hydrazine 3 in an environmentally favourablemoderate (ethanol) (Fig. 1). The structures of the products were determined by means of IR, 1H NMR, 13C NMR.