A novel and practical method for the selective synthesis of sulfonyl chlorides and thiosulfonates from thiols using Triazo-Cl-H2O2 as well as direct conversion of sulfonyl chlorides to sulfonamides and sulfonates

Developing versatile and eco-friendly methodologies that make easy the synthesis of biologically active organic compounds is in great demand. Organosulfur compoundshave attracted remarkable attention in recent years [1]. The Triazo-Cl-H2O2 as an effective and chemoselective reagent is developed for direct conversion of thiols to sulfonyl chlorides as well as synthesis of sulfonamides and sulfonates. Furthermore, thiosulfonates obtained by changing the Triazo-Cl/H2O2 molar ratio. High yields of products, short reaction time, and excellent selectivity are some of advantages of this method. In continuation to our reported works in this field [2] herein, we describe a new methodology for the oxidative chlorination of thiols using Triazo-Cl in the presence of H2O2 as a green oxidant at room temperature (Scheme 1).