Electrochemical investigation of acetaminophen/amlodipine interactions

In this research, electrochemical oxidation of acetaminophen was investigated in the presence of amlodipine, an amine-containing drug. The electrochemical techniquesused include cyclic voltammetry and controlled-potential coulometry. The results indicated that N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen can react with amlodipine, based on the Michael addition reaction [1,2]. Corresponding product was synthesized in aqueous solutions by means of electrosynthesis, using a carbon electrode in an undivided cell. It was an environmentally friendly method because in which the application of toxic reagents has been eliminated. Synthesized product was identified by FT-IR, 1H-NMR and 13CNMR spectroscopies. The cyclic voltammograms were analyzed by digital simulation to measure thehomogeneous parameters for the suggested electrode mechanism [3]. The observed rate constant (kobs) for the reaction of electrochemically generated N-acetyl-p benzoquinn-imine with amlodipine were calculated in various pH (e.g. kobs=652±32.6 (M-1s-1)).