Synthesis, structural characterization and cytotoxic activity of Mn(IV)complex of dithiocarbazate

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 214

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شناسه ملی سند علمی:

IRANCC20_395

تاریخ نمایه سازی: 28 اردیبهشت 1398

چکیده مقاله:

Cellular resistance and systematic toxicity are the two major defects of platinumbased anticancer drugs. Complexation of tridentate ONS-chelating ligands of dithiocarbazates derivatives with metals such as Mn is known in chemotherapeutic properties including antitumor effects. A new Mn(IV) complex, [MnL2] (Fig. 1) [L: Sethyl- 3-(2-hydroxyphenyl)methylenedithiocarbazate)], is synthesized and characterized using single crystal X-ray diffraction analysis, mass spectrometry and IR spectroscopic technique. This compound crystallizes in the monoclinic system with C21/c space group. Single crystal X-ray diffraction analysis reveals that the complex has distorted octahedral structure and each of the two ligands are coordinated to the metal ion through phenol oxygen, azomethine nitrogen and thioamide sulfur donor atoms. This coordination selects cis configuration for the two phenolic oxygen and also thioamide sulfur atoms, and likewise the configuration of the trans for two azomethine nitrogen atoms compared to their counterpart in the opposite ligand. The π∙∙∙π (4.342 Å) and C4-H4∙∙∙S1i (2.920 Å) (symm. code i: 1/2-x, 1/2-y,1-z) interactions lead to the formation of the dimer. These dimers interact to grow a one-dimensional ribbon along the a direction. Moreover, in vitro cytotoxicity of the complex against the MCF-7 (Human Breast cancer cell) and Hela (Human cervical cancer cell) cells was assayed by MMT method. Cytotoxicity study shows that the complex has significant activity against human cervical cancer cell line.

نویسندگان

Zahra Yekke-ghasemi

Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

Reza Takjoo

Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran