Synthesis of pyridine derivatives using a novel nanostructured molten salt catalyst via anomeric based oxidation

The pyridines, especially the polysubstituted pyridines are significant class of biologically active heterocycles. Most of these pyridines have potential for pharmaceutical activities and could be used as antimalarial, antitumor, antiepileptic, anesthetic, vasodilator, anticovulsant and agrochemicals. 2-Amino-3-cyano-pyridine derivatives were reported as potent inhibitor of HIV-1 integrase and A2A adenosine receptor antagonists. 2-Amino-3-cyanopyridines are substantial and appropriate intermediates in producing a variety of heterocyclic compounds [1-3]. In this report in, in continuation of our recent studies on design and synthesis of ILs, MSs and MCRs, we elicit the synthesis of 5-amino-7-aryl-2-oxo-2,3- dihydrothiazolo[4,5-b]pyridine-6-carbonitriles through a one-pot four-component reaction via anomeric based oxidation (ABO) under solvent-free condition using a catalytic amount a nanostructured molten salt (Scheme 1). The scope and limitations of described methodology will be presented.