Green synthesis and characterization of Betti bases derivatives by NS-PCS and FHS as the catalyst via Mannich reaction

In the current world, issues that pertain to our environment are of especial importance. One of these issues is the pollution caused by chemical compounds during their production process. As a result, finding chemical synthesis methods that are consistent with environmental protocols are also important. Multicomponent reactions (MCRs) are one of the best ways of developing green chemistry. In recent years MCRs have become a vigorous tool for synthesis of complex building blocks of prodrugs[1]. The catalytic performance of the α-aminoalkyl-β-naphthol derivative material, in water as a green solvent has been examined in the synthesis via MCR Mannich reaction of aldehydes, β-naphthol, and amines by porous carbon spheres which doped by Nitrogen and Sulfur (NS-PCS)[2] and Ferric Hydrogen Sulfate (FHS)[3]. The catalysts were easily separated from the reaction mixture and reused for several consecutive runs without significant loss of their catalytic efficiency.