The preparation and characterization of BNPs-SO3H: a highly efficient and reusable nanocatalyst for the preparation of 5-substituted 1H-tetrazoles

Today, development of nano-chemistry allows to preparation of nanocatalysts which include the benefits of both groups of heterogenous and homogeneous catalysts. [1] On the one hand, nano-catalysts are similar to those of heterogeneous catalysts, easily separated from the reaction mixture and on the other hand, they have the same activity and selectivity as homogenous catalysts. [1] Boehmite is an oxyhydroxide (AlO(OH)) particles, which has an orthorhombic structure and its surface is covered by hydroxyl groups. Thermal and mechanical stability, high surface area, ease of handling and the low costs of the required materials, are benefits of boehmite nanocatalyst. [2] Tetrazole derivatives having one carbon and four nitrogen atoms and these compounds are not found in nature.[2] Tetrazole derivatives show various biological properties such as antimicrobial, anti-inflammatory, anticancer,…[3]Here, we introduced BNPs-SO3H as a highly effective nanocatalyst for the synthesis of 5-substituted 1H-tetrazoles using sodium azide, malononitrile and various aldehydes (Scheme 1).