C−S Bond Formation Via C-H Bond Activation Catalyzed by Co(ll)-Immobilized Silica- Based Magnetic Retrievable Nanocatalyst

The formation of C−S bonds by method C-H bond activation leading to the synthesis of aryl sulfides is one of very significant strategies in organic chemistry, [1] as severalbioactive compounds with broad spectrum therapeutic activities for the treatment of some disease such as Alzheimer, Parkinson, diabetes, anti HIV, anti-inflammatoryand immune diseases contain aryl sulfides moieties [2]. Rostami et al. reported green and mild procedures for the C-S bond formation via C-N and C-O bond cleavage [3].Recently, Zolfigol and co-workers have developed Synthesis of 2-(aryl/alkyl-thio) phenols via sp2 C-H bond activation using the reaction of phenols with thiols in the presence of CoCl2 as catalyst [4]. In continuation of our reseach on the development of task-specific catalyst, we wish to report a novel Co(ll) supported-nanomagnetic core-shell catalyst for the preparation of aryl sulfide derivatives under mild and green reaction conditions. The presented protocol shows different advantages such as heterogeneous nature of the catalyst which allow an easy separation of the catalyst from the reaction mixture through applying a simple external magnet. Scheme 1 portrayed applied ligand which connected to the surface of magnetic nanoparticle and the style of reaction.