Analysis of antidepressant drugs by using HS-SPME based on nano-structured conductive polymer fiber couple to ion mobility spectrometry

This work describes the development of a simple, rapid, and selective method based on headspace solid-phase microextraction combined with ion mobility spectrometry(IMS-HS-SPME) equipped with corona discharge ionization for determination of antidepressant drugs such as sertraline, imipramine and alprazolam. The fiber was coated using electrochemical deposition technique. The effect of type of anion dopants on the extraction characteristics of the fiber was investigated. The sulfonated reduced graphene oxide (SRGO) and dodecyl benzenesulfonate were used as anion dopant. The extraction properties of these two fibers toward antidepressant drugs were studied using a HS-SPME devise. The results showed that PPy-DS possesses a better efficiency toward the sertraline than PPy doped with PPy-SRGO. The HSSPME system was equipped with a cooling device on the upper part of the sample vial and a circulating water bath for adjusting the sample temperature [1]. The HSSPME conditions such as solution pH, extraction time, extraction temperature, salt effect, desorption time, and desorption temperature were investigated and optimized [2]. The calibration graph was linear in the range from 100 ppb to 3 ppm, and the detection limit was 100 ppb. Finally, the proposed IMS-HS-SPME method was applied for analysis of antidepressant drugs in real samples