Synthesis of Xanthene and Dihydroquinazolin-4(1H)-ones by fructose catalyst

Xanthene, Benzoxanthene and 2-Amino-chromene and its derivatives represent an important class and very useful compounds in various fields of chemistry. These molecules are biologically active and find application in pharmacological, medicinal [1]. Also, Dihydroquinazolin-4 (1H) -ones constitute an important class of heterocycliccompounds that have been widely exhibited spectrum of biological, physiological activities and pharmacological properties [2], such as anticancer, antidiuretic, anticonvulsant, antibacterial, antifungal activity [3] and mono-amine oxidase inhibition and are also used as 5-hydroxytryptamine (5-HT) receptor ligands. Recently,Lindsley and coworkers observed the metabotropic glutamate receptor (mGluR) properties of this class of compounds. In this project, sulfonated fructose used as a new, non-toxic and effective catalyst for benzaldehyde, 2-naphthol and dimedone for the synthesis of tetrahydrobenzo [a] xanthene-11-one and the reaction of aldehyde and 2-naphthol to synthesize 14H-DI benzo [a, j] Xanthene. Advantages of this method are: the use of inexpensive, affordable and non-toxic catalyst, high efficiency, relatively short response times, simple product purifications, good to excellent yields.