Investigation of the Formation of Arachidonic Acid Micelle in Aqueous Medium

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 283

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شناسه ملی سند علمی:

IRANCC20_784

تاریخ نمایه سازی: 28 اردیبهشت 1398

چکیده مقاله:

Arachidonic acid is a 20-carbon fatty acid that plays the role of hormone in the human body. Due to the hydrophobicity of the nonpolar tail, it forms molecular aggregates or micelles in aqueous medium [1,2]. Using the Gromacs software [3] with the Gromos96 43A1 force field, formation of arachidonic acid aggregates was studied in aqueous medium at 300 Kelvin. This study has been conducted on molecular systems of up to 100 molecules. The shape of the molecular aggregates was analyzed by the VMD software.In the low number, the arachidonic acid molecules are mostly dispersed and far apart, in addition to a few binary and triple complexes (Fig. 1A). By increasing the concentration of arachidonic acid, the formed micelles exhibit volumetric growth, indicating an increase in the number of arachidonic acid molecules per micelle. Thesystem consists of a large number of small micelles up to 50 molecules. The number of micelles decreased in the presence of more than 50 molecules (up to 100 molecules) and volume of remaining micelles increased (Fig. 1B). It is indicating that smaller micelles added together and made larger micelles

نویسندگان

Seyed Habib Allah Mousavi

Department of Chemistry, Faculty of Science, Payam Noor University, Tehran, Iran

Zahra Sharafi

Department of Chemistry, Faculty of Science, Payam Noor University, Tehran, Iran