Protective effect of anethum graveolens L. seed extract (AGSE) on the oxidative stress in ovary of hypercholesterolemia rats

Background: Hypercholesterolemia is considered to be a major risk factor in the progression of coronary atherosclerosis and is associated with increase in the incidence of cardiac events. Oxidative stress is a state related to increased cellular damage caused by reactive oxygen species(ROS). Using antioxidants such as anethum graveolens L. reduces oxidative stress. In this study, the effect of AGSE on the oxidative stress markers in ovary of hypercholesterolemia rats was investigated.Methods: In this experimental study, 24 female Wistar rats were randomly divided into four groups: Control, Control received AGSE (500mg/kg/day), high fat diet-induced hypercholesterolemia and hypercholesterolemia with AGSE (500mg/kg/day) for 30 days. At the end, the right ovary was removed for measurement of oxidative stress enzymes including malondialdehyde (MDA) and catalase (CAT). Data was analyzed with spss software by one way ANOVA.Result: The results showed that the level of MDA enzymes activity was increased in hypercholesterolemia rats but the level of CAT enzymes activity decreased in the ovary. Treatment with the AGSE significantly reduced the level of MDA enzymes activity and increased the level of Catalase (p Conclusion: The results of this study confirm the antioxidant role of anethum graveolens L. extract in improving the ovarian damage caused by hypercholesterolemia

کلیدواژه ها:

Hypercholesterolemia ، Ovary ، Oxidative stress ، Anethum graveolens L