Wheat germ oil subdues carbon tetrachloride-induced asthenozoospermia in mice

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 367

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شناسه ملی سند علمی:

ISERB03_136

تاریخ نمایه سازی: 11 خرداد 1397

چکیده مقاله:

Background: Wheat germ oil (WGO) as one of the nature s best sources of vitamin E is known for its antioxidant properties. This study was undertaken to explore the possible protective effects of WGO on epididymal sperm motility in male mice exposed to carbon tetrachloride (CCL4).Methods: Forty-eight adult male mice were randomly categorized into 6 equal groups (n = 8) including untreated control, CCL4 (50%, 1 mL/kg; IP), CCl4 + WGO (250 mg/kg; PO), CCl4 + WGO (500 mg/kg; PO), WGO (250 mg/kg; PO) and WGO (500 mg/kg; PO). Epididymal sperm motility of all animals was examined after 28 days.Result: Significant sperm motility reduction was observed in CCL4-treated mice in comparison with control ones. Remarkably, WGO co-treatment in mice led to considerable sperm motility increase compared to CCL4-exposed mice. These findings suggest that WGO as a potent cyto-protective compound can suppress CCL4-induced asthenozoospermia in mice.Conclusion: WGO improved adverse effects of oxidative stress on asthenozoospermia.

نویسندگان

Fatemeh Rezazadeh

Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran

Ali Shalizar Jalali

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Fatemeh Rahmani

Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran

Gholamreza Najafi

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran