Effects of crataegus aronia hydro-alcoholic extract on antioxidant machinery in hypercholesterolemic rats ovary

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 347

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

ISERB03_145

تاریخ نمایه سازی: 11 خرداد 1397

چکیده مقاله:

Background: Increased plasma cholesterol is known to cause ovarian damages through oxidative stress (OS) induction. The main goal of current study was to determine the effects of hydro-alcoholic extract of crataegus aronia (HECA) as a potent antioxidant on oxidant/antioxidant status in hypercholesterolemic rats ovary.Methods: In this experimental study, 24 female Wistar rats were randomly assigned into 4 equal groups including: control, HECA (200 mg/kg/day), diet-induced hypercholesterolemia (DIH) and DIH + HECA groups. After 30 days, ovaries were quickly removed following euthanasia in order to analyze the malondialdehyde (MDA) level and catalase (CAT) enzyme activity in all experimental groups.Result: Hypercholesterolemia resulted in a significant reduction in CAT activity with an increase in MDA level in the rat ovaries. Interestingly, HECA co-treatment significantly restored above-noted values compared to DIH group.Conclusion: The results suggest that HECA can play a protective role against OS-evoked ovarian damages in hypercholesterolemic rats.

نویسندگان

Sakineh Falahati

Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran

Farah Farokhi

Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran

Gholamreza Najafi

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Ali Shalizar Jalali

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran