The effects of anethum graveolen seed hydroalcoholic extract(ASHE) on oxidative stress in testis of induced hypercholesteroleomia male rats

Background: Hypercholesterolemia is a major risk factor for cardiovascular diseases and it is considered a wellknown herb in traditional medicine with various medicinal properties. In the present study, protective effect of ASHE was investigated in the hypercholesterolemic male rats.Methods: In this experimental study, twenty-four 170±5gr male Wistar rats were allocated to four groups of 6: Control group having a normal diet, experimental group receiving a high-fat diet, two experimental groups receiving high-fat diet and ASHE at maximum (500and minimum (300) mg/kg by oral rout for 48 days. At the the end of this period, all of the rats were killed and the testis were removed to the _70C for stress oxidative assessment.Result: Lipid peroxidation products significantly decreased in testis compared with the high-cholesterol diet alone, while Catalase content and antioxidative enzymes activities were enhanced. This function can be attributed to the presence of large quantities of antioxidants in the plant and their cholesterol synthesis inhibition mechanisms.Conclusion: These results suggest that ASHE may have a protective effect against oxidative stress, hypercholesterolemia induced by high-cholesterol diet.

کلیدواژه ها:

Hypercholesterolemia ، Oxidative stress ، Testis ، Anethum graveolen