Level of blood glucose and insulin resistance in premenstrual syndrome

Background: Premenstrual syndrome (PMS) is suspected to be the result of dysregulation of the serotonergic system. Serotonin not only regulates glucose and estradiol levels but also affects insulin resistance and blood glucose levels, and it can stimulate or intensify PMS symptoms. According to this, we compared the blood glucose levels, insulin concentrations, and insulin resistance during the two phases of the menstrual cycle between healthy women and patients with (PMS).Methods: From January of 2014 to the August of 2015, a descriptive cross-sectional study was performed among students in the School of Medicine of Jahrom University of Medical Sciences. We included 62 students with the most severe symptoms of PMS and 62 age frequency-matched healthy controls. We analyzed the serum concentrations of glucose, insulin, and insulin resistance by using the glucose oxidase method, radioimmunometric assay, and homeostasis model assessment of insulin resistance equation, respectively.Result: No significant differences between the demographic data of the control and PMS groups were observed. The mean concentrations of glucose of the two study groups were significantly different during the follicular and luteal phases (p=0.023 vs. p Conclusion: The level of blood glucose and insulin resistance was lower during the two phases of the menstrual cycle of the PMS group than that of the controls.

کلیدواژه ها:

Insulin resistance ، Premenstrual syndrome ، Glucose