The effect of vitamin E(VE) on in vitro fertilization (IVF) in oxidative stress induced by nonylphenol

Background: Infertility is a sad reality and it is now evident that several aspects of male reproductive health have changed for the worse over the past 30–50 years. Nonylphenol (NP), an environmental toxicant with oestrogenic properties, was tested for its effect on male fertility potential.Methods: In this present experimental study, 30 adult male mice (6-8 weeks) were randomly divided into three groups including control and test groups. The control group received corn oil orally and the test groups were treated with NP (225mg/kg), NP+vit E (325 mg/kg) for 35 consecutive days orally by gavages. After 35 days, all animals were sacrificed. Then, sperm samples were collected from caudal epididymis in order to evaluate the sperm parameters and in vitro fertilizing (IVF) analyses. Then, sperm count, viability, and motility were determined.Result: The NP-treated animals showed significant changes in all parameters of sperm quality compared to the control group (p Conclusion: NP destroys the sperm fertiliry in adult rats by inducing oxidative stress, and this damage could be partially reversed by VE.

کلیدواژه ها:

Embryo ، Fertilization ، Vitamin E ، Sperm