Test the association between gene polymorphism CPEB1 and CPEB2 risk men with azoospermia / oligospermia

Background: Infertility as the inability to conceive after one year of regular intercourse without using contraception is defined. Infertility is not just a dependent agent and many factors involved in it. 15 percent of couples suffer infertility problems that among them about 35 percent of infertility is due to male factors. CPEB gene mRNA sequences that code for specific proteins in the growth, health, disease control involved.Studies have shown that the presence of CPEB SNP in the gene cause changes in miRNA binding sites and increased risks of genetically complex diseases such as idiopathic infertility in men.Methods: This study is a case-control study (Case-Control) on 100 blood samples of oligo / azoospermia and 100 blood samples of healthy men (have children with no problem and no family history of infertility) .Of each blood sample, 5ml environmental and genomic DNA will be extracted using Salting-out method.Result: Density of the obtained genotype polymorphisms in both patients and controls showed no significant difference (P = 0/422). A significant difference was seen in age between the genotypes (P = 0/19) and slow the disease progression (P = 0/65).Conclusion: Considering the role and impact of infertility and infertility genes CPEB1 and CPEB2, the review of other factors is also recommended .

کلیدواژه ها:

Azoospermia ، CPEB2 ، Oligospermia ، CPEB1