Protective effect of L- carnitine on testis in ciprofloxacine treated adult mice

Background: Ciprofloxacin is a commonly prescribed antibiotic in the treatment of many infections for long time. The aim of the present study was to investigate the effect of L-carnitine administration on physiology and testicular structure in ciprofloxacine treated adult mice.Methods: Twenty adult male mice NMRI were divided into four groups (n=5); control group received normal saline, we subdivided the test group into, 12.5 mg/kg ciprofloxacin, 100 mg/kg L- carnitine , 100 mg/kg L- carnitine + 12.5 mg/kg ciprofloxacin, treated(i.p) for 15 days. Body and testes weighed, sperm parameter and histological structures were measured in groups.Result: Ciprofloxacin significantly decreased the diameter and lumen of the seminiferous tubule, weight testis, number of spermatocyte, round and along spermatid , sperm count, viability, motility compared with the control group(p≤0.05), an it significantly increased the diameter seminiferous tubule, weight testis, number of round and along spermatid, sperm count, viability, motility, compared to L- carnitine + ciprofloxacin with ciprofloxacin group(p≤0.05).Conclusion: It is concluded that L- carnitine administration cause an improvement in gonadotoxic ciprofloxacin effects , spermatogenesis and become sperm parameters in adult Mice.

کلیدواژه ها:

Ciprofloxacin ، L- Carnitine ، Sperm parameters ، Spermatogenesis ، Testis