Nanocurcumin as a promising agent for diminution of oxymetholone induced reprotoxicity in mice

Background: Oxymetholone (OXM) as an active nutritional 17α-alkylated anabolic-androgenic steroid has been reported to induce spermatogenic arrest. The aim of this study was to explore the effects of nanocurcumin (NAC) administration on epididymal sperm fertilizing potential and subsequent embryo development following OXM treatment in mice.Methods: Adult male mice were randomly divided into 4 equal groups including control, OXM (5 mg/kg; PO), NAC (15 mg/kg; PO) and OXM+NAC. Epididymal sperm fertilizing capability and followings.Result: Oxymetholone therapy resulted in remarkable reductions in fertilization, two-cell embryos, blastocysts and hatching rates. Interestingly, NAC co-administration led to significant improvements in above-noted parameters.Conclusion: These findings suggested that NAC can be a promising agent for reduction of OXM-induced reproductive side effects. However, more researches are required in order to propose NAC as a safe reproprotective compound in humans.

کلیدواژه ها:

Curcumin ، Embryology ، Fertility ، Mouse ، Oxymetholone