Antifertility activity of nicotine in male mice: The protective effect of royal jelly

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 409

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شناسه ملی سند علمی:

ISERB03_311

تاریخ نمایه سازی: 11 خرداد 1397

چکیده مقاله:

Background: Smoking is a major factor that lead to male infertility. Nicotine as one of the most important hazardous substrates in cigarette is reported to directly impair male fertility and embryo development. The aim of this work is to show whether antifertility agent with protective effect of royal jelly(RJ).Methods: In this study, 36 male balb/c mice weighing 25-30 g were randomly divided into six groups(n=6) .Group 1 received 0.2 normal salin (control), group 2 received 100 mg/kg RJ, group 3 and 4 received 0.5 mg/kg and 1.0 mg/kg of nicotine respectively, group 5 received 0.5 mg/kg of nicotine with 100 mg/kg of RJ, group 6 received 1.0 mg/kg nicotine and 100 mg/kg RJ. All administration were done orally. After gavage for 30 days, fertilizing capacity of epididymal sperm and blastocyst rate of all animal was evaluated following in vitro fertilization.Result: The results showed that fertilization and blastocyst rate decreased significantly (pConclusion: These results suggested that royal jelly may be improved adverse effect of nicotine on fertilization and blastocyst rate and fertilized oocyte.

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نویسندگان

Farnam Azad

Department of Biology, Faculty of Science, Urmia university, Urmia, Iran

Gholamreza Najafi

Depatment of Basic Scienses, Facullty of Veternary Medicine, Urmia University, Urmia, Iran

Vahid Nejati

Department of Biology, Faculty of Science, Urmia university, Urmia, Iran

Fatemeh Rahmani

Department of Biology, Faculty of Basic Science, Urmia University, Urmia, Iran