The protective effect of green tea extract on ovary function of mice treated by anti-cancer drug paclitaxel

Background: Paclitaxel is an anticancer drug commonly used to treat ovarian cancer. Its destructive effects on ovary have been proved by several researches. The anticancer, antioxidant and chemoprotective effects of green tea may protect ovary from destructive effects of paclitaxel.Methods: In this study effects of 2 doses (200, 300 mg/kg) of green tea extract on paclitaxel-treated mice were investigated. 35 NMRI adult female mice (8 weeks) divided into 6 groups: Control received Saline as Solvent. Experimental 1 were intraperitoneally injected 0.2 mg/kg of paclitaxel for 3 consecutive days. Experimental 2 ,3 treated with 200 mg/kg , 300 mg/kg of GTE (green tea extract) respectively daily for 4 weeks. (i.p. injection) . Experimental 4,5 treated with 200 mg/kg , 300 mg/kg of GTE respectively daily for 4 weeks. (i.p. injection). Starting at the second week 0.2 mg/kg of paclitaxel for 3 consecutive days were intraperitoneally administered. One week after the last injection blood samples for determination of FSH, LH levels were collected and ovarian weight was measured before and after treatment. Parameters of ovarian tissue after tissue slices were examined, results of ANOVA and pResult: Paclitaxel treatment caused a significant decrease (pConclusion: Green tea extract is an antioxidant protective effect on mouse ovarian tissue parameters and levels of LH, FSH after treatment with paclitaxel

کلیدواژه ها:

FSH ، Green tea ، LH ، Ovary ، Ovary ، Paclitaxel