Main Embryonic Factors in Recurrent Implantation Failure

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 409

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شناسه ملی سند علمی:

ISERB04_047

تاریخ نمایه سازی: 16 تیر 1397

چکیده مقاله:

Repeated implantation failure (RIF) is a big challenge in fertility field that mostly occurred due to fault dialogue of embryo during implantation. Both maternal and paternal factors could affect embryo dialogue with endometrium. Maternal factors influence on embryo quality by impression of oocyte competence. Although the portion of maternal factors in embryo quality is much higher than paternal factors, sperm DNA integrity could strongly affect embryo development and also implantation fate. Some new techniques like IMSI probably assist to select spermatozoa with low levels of DNA damage. Beside quality of oocyte and sperm, culture condition and laboratory quality control are key factors in embryo development. Therefore, embryo culture using high quality media and coculture system sounds to improve the embryo quality. Moreover, assisted hatching and transfer of embryos at the blastocyst stage are other suggestion to increase implantation chance, clinical pregnancy and ongoing pregnancy rates. Itis noticeable that morphological appearance of embryo could not warrant embryo normality; such some embryos with chromosomal aneuploidy have high quality appearance and maybe develop normally until blastulation. Monitoring of embryo development by time lapse imaging and preimplantation genetic screening have been suggested to choose euploid embryo. Apart of embryo quality, embryo-endometrial developmental asynchrony could lead to implantation failure. Evidence suggests that the human embryo implantation rate is significantly reduced when asynchrony between the embryo and the endometrium is greater than ±1.5 days. Endometrial receptivity array and freeze all embryo policy have recently proposed to increase embryo-endometrial developmental synchroniczation and improve implantation rate.

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نویسندگان

Somaieh Kazemnejad

Reproductive Biotechnology Research Center, Avicenna Research institute, ACECR