Review study: Sperm washing and assisted reproductive technology in HIVdiscordant couples.

Background: HIV affects mostly men and women in their reproductive years. 37 million people worldwide are infected with HIV and 86% reproductive age group are 15-44 years. today, serodiscordant couples  consider having children. Assisted reproduction techniques can reduce the risk of infection. Sperm washing coupled with (IUI),( IVF) or (ICSI) is safely used in serodiscordant couples.the aim of this study is to evaluate the effectiveness of semen washing in HIV-discordant couples in which the male partner is infected.    . Method: all papers on Sperm washing and assisted reproductive technology in HIVdiscordant& nbsp; couples indexed in databasesmedline,chochrane libraray and such journals as springer, SCOPUS during January 2008- January  2018 were explored.at first 190 relevant papers were found and finally 9 ones were chosen based on inclusion criteria of present study.   Finding: 5 studies were retrospective and 4 prospective. In total, 1429 couples were examined. For the preparation of sperm, in all 9 studies, the technique of Discontinuous density gradient had been used and in 6 studies swim-up technique was added to it. 4 studies were withIVF+ ICSI, 2 studies were with IUI, 2 studies were with IVF+ICSI + IUI and 1 study was with ICSI. The techniques used after sperm washing in 3 studies were Real-time, in 4 studies were RTPCR and 2 studies were with both methods. No HIV transmission occurred in any study.   Conclusion: ART with sperm washing may help HIV-discordant couples achieve pregnancy and integration of semen washing into HIV prevention intervention could help further reduce.

کلیدواژه ها:

HIV ، Assisted reproduction ، Sperm washing ، Reproductive techniques