Testicular Volume and Number of Leydig Cells Alterations in The Diabetic Mice: A Stereological Study

Background: Because of the paucity of studies regarding the impact of diabetes mellitus (DM) on semen quality, this disease is seldom looked for in the infertile patient. However Type one diabetes mellitus (DM) reduces testosterone,and also affects spermatogenesis through modulating testis tissue. The aim of current study was to spermatogenesis and total number of leydig cells in type one diabetic mice.Methods: 20 male type one diabetic mice were divided randomly into healthy, and diabetic groups: (1) control groups; (2) diabetic groups. Type one DM was induced by injection one time of 200 mg/kg streptozotocin(STZ).After 35 days, the testis were removed and volume of the testis and total number of leydig cells were estimated using stereological methods.Results: The total volume of the testis and total number of leydig cells were decreased in diabetic mice comparison control groups.Conclusion: The result indicated that diabetes could induce significant decreases in the total volume of the testis and total number of leydig cells.

کلیدواژه ها:

Type One Diabetes Mellitus ، Spermatogenesis ، Stereology