Comparion Effects of Atorvastatin and Garlic powder on the Ovary in Hypercholesterolaemia Rats

Background and purpose: Hypercholesterolemia is associated with high levels of cholesterol in the blood. Studies have shown that statins have a potent effect on blood cholesterol but still have side effects. The compounds in the garlic have antibiotic properties and prevent the formation of cholesterol. The aim of this study was to evaluatethe effect of garlic powder and atorvastatin on reproductive system of hypercholesterolemic female rats. Materials and Methods: In this experimental study, 48 adult female rats were randomly divided into 8 groups of 6, including control, atorvastatin (10 mg/kg.bw), atorvastatin (20 mg/kg.bw), garlic (100 mg/kg.bw), Cholesterol (1/5 mg/kg.bw),Cholesterol + atorvastatin (10 mg/kg.bw), Cholesterol + atorvastatin (20 mg/kg.bw) and Cholesterol + garlic. After 30 days, ovaries all groups, were weighed separately and were placed in a 10% formalin solution for histological analyses. Results: The results of this study showed that in the hypercholesterolemia group, there was a significant decrease in the number of primordial, primary, secondary and adult healthy follicles, as well as a significant increase in the number of primordial, secondary and adult follicle atresia. Conclusion: Hypercholesterolemia can lead to significant ovary damages in rats. However, Garlic powder, however, was better than atorvastatins in improving the factors in hypercholesterolemic groups with garlic powder and atorvastatin 10 mg/kg.bw and 20 mg/kg.bw respectively.

کلیدواژه ها:

Atorvastatin ، Garlic ، Hypercholesterolemia ، Ovary ، Rat