Comparison of survival and prognosis of low and high risk groups in hormone receptor-positive breast cancers

Introduction: Tumor features can effect on survival and prognosis of early Breast Cancer (BC).Herein, we compared overall survival (OS) and disease-free survival (DFS) of hormone receptorpositive BCs into low- and high-risk groups. Materials and Methods: We divided the patients(Luminal or hormone receptor-positive) into two groups: 75 patients in low-risk group (thepatients undergoing hormone therapy) and 117 patients in high-risk group (the patients undergoinghormone and chemotherapy therapy). Univariate analysis and multivariate analysis was done forchecking the effect of the prognostic factors on the OS and DFS. Results: Age, tumor size, stage,grade, PR receptor, HER2 receptor, Ki67 index, and subtype had significant difference between twogroups. The 8-year OS rate was 98.7% vs. 98.3% [Hazard ratio (HR): 0.923; 95%CI: 0.086, 9.888;P=0.947] in low-risk group compared to high-risk group. In addition, the 8-year DFS rate was94.7% vs. 94% [HR: 0.968; 95%CI: 0.284, 3.298; P=0.956] in low-risk group compared to highrisk group. Multivariate analysis showed that laterality was an effective factor on DFS. Conclusion:The results showed that adding of chemotherapy therapy to endocrine therapy couldn’t significantlyeffect on OS and DFS of the hormone receptor-positive BCs. Therefore, further studies need to bedone with more patients and in different areas to confirm these results.