Survey Reaction of Benzoimidazolo/Benzooxazolo/Benzothiazolo 2-thioacetophenone Derivatives Using TiO2-Nanoparticles

2-((Benzimidazol-2-yl)thio)-1-arylethan-1-ones, 2-((benzothiazol-2-yl)thio)-1-arylethan-1-ones and 2-((benzoxazol-2-yl)thio)-1-arylethan-1-ones have various biological properties.There are various methods for synthesis of this heterocyclic compounds [1-3]. In this investigationbenzothiazolo-2-thioacetophenone, benzooxazolo-2-thioacetophenone and benzoimidazolo-2-thioacetophenone derivatives were synthesized in the presence of TiO2 nanoparticlesas catalyst in high yield. Firstly, 2- mercaptobenzoimidazole has been synthesis fromreaction of the orthophenylendiamine with amoniumisothiocyanide in the presence of amoniumchlorideas a catalyst by heating under solvent free conditions. Then this derivative, 2-mercaptobenzooxazole and 2-mercaptobenzothiazole have been reacted with phenacyl bromide/2-bromo 4ʹ-methoxyacetophenone/2-bromo 4ʹ-phenyl acetophenone using TiO2 nanoparticlesas catalyst by ball-miling and under solvent free conditions for synthesize of benzothiazole-2-thioacetophenone, benzooxazole-2-thioacetophenone and benzoimidazole-2-thioacetophenone.