Mixed Metal Oxides Modified Mesoporous Silica with Magnetic Core: A Reusable Catalyst for the Synthesis of 2-Substituted Pramipexole Dihydrochloride

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 240

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شناسه ملی سند علمی:

ISOC26_079

تاریخ نمایه سازی: 2 شهریور 1398

چکیده مقاله:

The use of magnetically recoverable catalysts has received considerable importance in organicsynthesis because of their ease of handling, simple work-up and recoverability. Among thevarious heterogeneous catalysts, particularly, mesoporuos supported catalysts have advantagesof high surface area and thermal stability. Metal modified mesoporous silica and alsomagnetically recoverable mesoporous silica have been applied in many organic transformations[1]. In this work, we wish to report an efficient method for the synthesis of 2-substituted pramipexole dihydrochloride from the reaction of alkylating and (S)-(-)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole with an alkylating agent, in the presence of catalyticamount of mesoporous silica containing AL metal oxides with magnetic core (Fe3O4@ALMCM)[2]. (***) Various types of (S)-(-)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole were reacted with analkylating agent, in the presence of catalytic amount of Fe3O4@AL-MCM-41 at reflux conditionand corresponding 2-sudstiuted pramipexole dihydrochloride were produced in highyields. Recovery and reusability of the catalysts was studied and results indicate that thecatalyst can be reused many times with moderate change in its activity. In conclusion, weintroduced a Fe3O4@AL-MCM-41 as simple, efficient and eco-friendly catalyst for the synthesisof 2-substituted pramipexole dihydrochloride. Simple workup and reusability of catalystsare other advantages of this method.

نویسندگان

Morteza Karimi Seresht

Department of Chemistry, Islamic Azad University, Sabzevar, Iran