Novel Phosphonium Based Ionic Liquid Catalyzed One-Pot Multicomponent Synthesis of 2-Oxo-4,6-diphenyl-1,2-dihydropyridine-3-carbonitrile Derivatives

Compare with conventional multi-step preparation processes, multi-component reactions representelegant advantages such as convergence nature, facile automation, simplicity of operationalprotocols, reduce the number of work-up steps, minimizing waste production, and renderingthe transformations based on green chemistry metrics [1-2]. On the other hands, ionicliquids represent unique features including excellent thermal and chemical stability, high electrochemicalproperties, good solubility, excellent potent of recyclability [3]. In this exploration,we combined the elegant characteristic of multicomponent reaction process and ionicliquids to present a facile synthetic routs for the preparation of 2-oxo-4,6-diphenyl-1,2-dihydropyridine-3-carbonitrile derivatives under mild reaction conditions (Figure 1). (***) Fig. 1 Synthesis of 2-oxo-4,6-diphenyl-1,2-dihydropyridine-3-carbonitrile derivatives using phosphonium basedionic liquid as catalyst