Synthesis of Diclofenac sodium imprinted microspheres and nanoparticles: Impact of porogens on their particle size and recognition properties

Molecular imprinting is a technique used for preparing polymers with specific binding cavities that possess functional groups complementary to those on the originaltemplate used. MIPs have been used in several configurations depending on the different analytical applications. The choiceand quantity of porogenic solvent used in a polymerization recipe affects both the imprinting process and the physical state (pore structure, pore size distribution, swellability,toughness and morphology) of the imprinted polymers [1]. In this paper imprinted microspheres and nanoparticles which aredemanded to satisfy the above criteria have been prepared by precipitation polymerization and using different porogens