Evaluation of Naltroxone Release Kinetic from In Situ-Forming Drug Delivery System (Investigating the Effect of Polymer End Group Functionality)

In order to explicate the important drug release mechanisms, mathematical modeling plays an important role so as to design a predictable pharmaceutical products and avoidance of tryingout various inconspicuous specimens [1]. In the present study the influence of polymer end group functionality on a modeldrug (Naltroxone) release profiles are analyzed using three semi-empirical models: First-Order, Hixson and Gallagher-Corrigan equations and the correlation coefficients were chosen to define the approximation accuracy of models