Investigating of HDF Cells Behavior on Gelatin/Chondroitin Sulfate Nanofibrous Scaffold for Skin Tissue Engineering

In this study, novel gelatin/chondroitin sulfate nano fibrous mats were successfully fabricated using electrospinning process. TFE/Water solvent system results in good solubility and electrospin ability at the same time. The best ratio of water in solvent system for having reasonable solubility was 50% (v/v). The potential use of gelatin/chondroitin sulfate electrospun scaffold in skin tissue engineering was evaluated using culturing of human dermal fibroblast cells (HDF). The SEM micrographs of HDF cells on the nano fibrous structure show that fibroblast cells can highly attach, grow and populate on the fabricated scaffolds surface. The electrospun gelatin/chondroitin sulfate nano fibrous mats have a potential for using as scaffold in skin, cartilage and cornea tissue engineering

کلیدواژه ها:

gelatin ، chondroitin sulfate ، skin tissue engineering ، electrospinning ، HDF cells