Synthesis of bio-polymers for use in controlled drug delivery systems based on starch: in vitro evaluation

methoxy poly (ethylene glycol)/ starch grafted copolymers (MPEG-g-Ss) were synthesized through Bromoacetylation of starch, followed by substitution with methoxy poly(ethylene glycol) (MPEG) with various molecular weights (MPEG-500, MPEG-2000 and MPEG-5000). The grafting was performed at 50°C. The structures of the copolymers were characterized by Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Thermal Gravimetric Analysis (TGA), X-ray Diffraction (XRD) and Atomic Force Microscopy (AFM). The loading of ceftizoxime antibiotic was carried out on prepared copolymers and in vitro drug release behavior was investigated in three different media (HCl solution: pH=3 and buffer solutions: pH=6 and pH=8).

کلیدواژه ها:

Starch ، Graft copolymerization ، Carboxymethyl Starch ، Ceftizoxime ، Control release