Synthesis and characterization of Nano magnetic molecular imprinted polymer for creatinine concentration measurement in vitro analysis

The magnetic molecularly imprinted nanoparticles were prepared in the presence of creatinine template. The magnetic creatinine molecularly imprinted nanoparticles (MCMN) was characterized the structure, size, adsorption and desorption, effect of salts on adsorption, selectivity, magnetic properties and thermal properties. The imprinting efficiency of MCMN was evaluated by contrasting the adsorbed amount of creatinine by MCMN with that by the corresponding non-imprinted polymer (NIP). The MCMN with 25 nm size range exhibited 99% loading efficiency Selectivity studies reveal that the MCMN possess a remarkable affinity for creatinine. Various factors influencing adsorption capacity such as contact time, pH, amount of Fe3O4 nanoparticles, and initial concentration of creatinine were investigated. The experimental data were analyzed by Langmuir and Temkin adsorption isotherm equations