The Effect of Solvent Type on Bupivacaine HCl Release from In-Situ Forming Implants Based on SAIB-PLGA

The purpose of this study was to investigation of Bupivacaine Hydrochloride release from an in-situ forming SAIB (sucrose acetate isobutyrate)- PLGA (poly (lactide-co-glycolide)) mixture matrix depot using different solvents. Solubility of drug into solvents and viscosity of depot before injection as effective factors on drug release were investigated. In addition, microscopic images from implants after injection were taken due to the more discussion. The initial release at first 24 hours for N-Methyl-2-pyrrolidone, Dimethyl Sulfoxide and Triacetin systems were found 30%, 18% and 12% respectively. The total drug release from NMP system was approximately achieved after 336 hours, whereas the amount of drug release from DMSO and Triacetin systems were shown 78% and 62% at the same time.