In vitro evaluation of thermal sintering as novel method for bone tissue scaffolds

Biodegradable scaffolds with good mechanical properties are goal of tissue engineering. In this work, we introduce the new method based on heating of polymer microparticles for adhesion them on their surfaces. In this method called as Thermal Sintering , we provide scaffolds using PLA, PCL and PCL/PLA and a series of evaluation tests were conducted for ideal scaffold characteristics such as structure and morphology, porosity, water absorption, biodegradability, mechanical properties, cell attachment and cell viability on scaffolds. All of three samples had good biocompatibility and cell proliferation such as control samples. The all of samples had suitable porosity, for example sample of PLA indicates the highest porosity percentage (90.6 ± 0.1%). Also water uptakes of samples were about of 14-20 % after 72 hours. So this method can be used for tissue engineering such as bone regeneration