The Role of Functionalization of Crbon Nanotube in Delivery of Gemcitabine

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 291

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شناسه ملی سند علمی:

ISPTC20_028

تاریخ نمایه سازی: 2 تیر 1397

چکیده مقاله:

In recent years, a lot of attention has been focused on nanoparticles as carriers for drug delivery. Nano-carriers can cause better performance and minimize side effects of drugs. This article explores the potential of carbon nanotubes for delivering anticancer drug, Gemcitabine with and without Folic acid and Chitosan. Using these groups help to decrease the deficiencies of carbon nanotube and increase the stability of the system. Drawing the structures and optimization the systems has been done by using HyperChem, Gauss View, Gaussian and Nanotube Modeler. Energy, dipole moment and NMR parameters (σiso, σaniso, Δσ and δ)of the systems were calculated by HF/STO-3G. Finally, it was observed that systems that were functionalized with Folic acid and Chitosan are proper agents for targeted delivery of Gemcitabine.

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نویسندگان

N Karachi

Department of chemistry, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

N Abidi

Department of chemistry, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran