Adipose tissue-derived stromal cells for wound healing

Wounds can affect skin layer negatively and disrupt its functions. Wound healing cascade as a biological process is initiated immediately after an injury. This process consists of three precise programmed stages: inflammation, proliferation, remodeling. Generally, these three stages occur continuously and timely. However, some factors can interfere with these stages and impede the normal healing process which results in chronic wounds. The financial burden on both patients and healthcare systems are numbers of issues which make chronic wounds as a considerable challenge. During recent years, along with advances in the biomedical sciences, various surgical and non-surgical therapeutic methods have been suggested. All of these suggested treatments have their own advantages and disadvantages. Recently, cell-based therapies and regenerative medicine represent promising approaches to wound healing. Accordingly, several types of cells have been used in both preclinical and clinical settings for the treatment of wounds. In medical studies, mesenchymal stem cells (MSCs) have considerable benefits for regenerating damaged tissues which are unable to heal on their own. Adipose-derived stromal cells (ASCs) are a cost-effective source of MSCs in wound management which can be easily harvested from adipose tissues through the less invasive processes with high yield rates. In addition, their ability to secrete multiple cytokines and growth factors, and differentiation into skin cells make them an ideal cell type to use in wound treatment. This is a concise overview of the application of adipose-derived stromal cells in wound healing and their role in the treatment of chronic wounds

کلیدواژه ها:

Adipose tissue ، Wound healing ، Mesenchymestromal cell ، chronic disease ، Regenerative medicine