The effect of polymer concentration and homogenizer rate on microspheres structure fabricated by double-emulsion method

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 333

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شناسه ملی سند علمی:

ITERMED01_101

تاریخ نمایه سازی: 7 مرداد 1398

چکیده مقاله:

Broadly speaking the application of polymeric microspheres in drug delivery and regenerative medicine has been extended in recent years. There are various methods to fabricate microparticles. In this study, double emulsion method (W1/O/W2) is utilized for preparing microspheres. The effect of polyvinyl alcohol (PVA)concentration in W1 and W2 as well as homogenizer rate on microsphere structure has been investigated in the present research. To study the structure of microspheres, Scanning Electron Microscopy (SEM) device is employed. For preparation of microspheres, polycaprolactone (PCL) polymer (1.5% w/v) is dissolved in dichloromethane as the oil phase and PVA polymer (1% and 3% w/v) is dissolved in double distilled water as the water phases. In order to fabricate (W1/O) emulsion, homogenizer has been used and influence of various rates on microparticles structure is analyzed. The results depict that homogenizer rate has a significant effect on microspheres formation and eventually the rate of 12700 rpm is selected as the optimum rate. Furthermore, the SEM images indicate that the percentage of PVA has considerable impact on microspheres structure. The results prove that by increasing the PVA concentration in water phases, the size of microparticles decreases.

نویسندگان

Amir Shamloo

Departpent of Mechanical Engineering, Sharif University of technology, Iran.

Homa Afjoul

Departpent of Mechanical Engineering, Sharif University of technology, Iran.

Yeganeh Dorri Nokoorani

Departpent of Mechanical Engineering, Sharif University of technology, Iran.

Maedeh Bahadoran

Departpent of Mechanical Engineering, Sharif University of technology, Iran.