Induced pluripotent stem cell therapy for central nervous system repair: moving forward to the clinic

Since their discovery to date, induced pluripotent stem cells (iPSCs) have moved gradually from basic research towards clinical trials and medical use for central nervous system (CNS) injuries and diseases. Although basic iPSCs research has opened the opportunity of using this cells for several clinical therapies; however, translating these treatments to the clinic has been limited to only a few disorders. Lately, the scientists have developed new technologies to manipulate transplanted cell function and integration behavior in the CNS to increase their therapeutic effectiveness that pushed the borders of what may be achievable in CNS repair using iPSCs.We have searched the PubMed databases comprehensively and accurately to find peer-reviewed articles concerning the application of iPSCs in CNS diseases and the clinical trials in this field.In this review, the authors discussed the potentials of using iPSCs in CNS disease treatments and the future prospects. The reviewed papers provided enormous data on using iPSCs to treat CNS disorders and injuries. There were some clinical trials using this approach to treat some diseases and also injuries such as Parkinson’s disease and spinal cord injury.Using iPSCs in CNS disorder treatment is a newly emerging approach in stem cell research/therapy that could provide an enormous supply of autologous cells for transplantation to treat CNS disease or injury. The therapeutic potential of iPSCs are limitless but there are some boundaries for successful iPSCs application such as the safety problems of iPSCs use in cell replacement therapy

کلیدواژه ها:

Induced pluripotent stem cell ، Central nervous system ، Clinical trial ، Tissue engineering ، Regenerative medicine