Honey properties and application on skin tissue engineering

Honey is a bee-derived, supersaturated solution composed mainly of carbohydrate such as fructose, glucose and containing proteins, enzymes, minerals, amino acid, vitamins and other minor components. For Centuries, honey has been used for medicinal applications and in World War I soldiers used honey for burning wounds. The high sugar concentration, hydrogen peroxide and low pH value are well-known antibacterial factors in honey. More recently, methylglyoxal and antimicrobial peptide bee defensin-1 had been identified as important antibacterial compounds in honey. Antimicrobial properties are pivotal in dermatological applications, owing to enzymatic H2O2 release or the presence of active components like methylglyoxal in manuka, while medical-grade honey is also available. Honey is particularly suitable as a dressing for wounds, burns and has also been included in treatments against dandruff, diaper dermatitis and psoriasis. Thedistinction nutritional behaviorof bees to collect the nourishments from different and various solutions creates different compositions in produced honeys. In this review, we found that there is no allergic reaction and no significant side effects due to clinical application of honey. Finally, we conclude that honey has all beneficial criteria for scaffolds and wound healing in skin tissue engineering.

کلیدواژه ها:

Honey ، Tissue engineering ، Dressing biomaterial ، Wound healing ، Skin scaffolds