A review on electrospun wound dressings

Wound dressings have experienced tremendous changes since the ancient times. The development starts with the use of passive materials to simply cover the wounds to the dressings of the present time that can actively interact with wounded tissue to exhibit various extraordinary functions. Among fabrication methods, electrospinning has gained therapeutic appeal, over the past decade. The inherently high surface to volume ratio of electrospun scaffolds can enhance cell attachment and drug loading efficiency. Various materials can be electrospun including: biodegradable, non-degradable, and natural materials. Electrospinning parameters can be tailored giving control over both the bulk mechanical properties and the biological response to the scaffold. The modern wound care materials, made of electrospun biopolymers, may contain various therapeutic agents such as antioxidant, growth factors, antibacterial, and anti- inflammatory agents, which could be slowly released to the wounded tissue promoting the healing process. These scaffolds have structural similarity to native extracellular matrix with the size of fibers ranging from tens of nanometers to micrometers. With the right choices of biomaterials used for the fabrication of matrices, they could exhibit significantly higher healing potential compared with the conventional fibrous dressing materials, such as sterile gauze.

کلیدواژه ها:

Electrospinning ، Wound dressings ، Nanofibers