Challenges of 3D bioprinting commercialization

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 438

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ITERMED01_241

تاریخ نمایه سازی: 7 مرداد 1398

چکیده مقاله:

Bioprinting is a novel technique that is considered as a new concept in tissue engineering. 3D bioprinting has felt its analysis career and turning into a strong tool for producing of human body tissues. The main challenge of 3D bioprinting is, needing vascularization in vivo to supply the cells with sufficient nutrition, growth factors, oxygen and remove carbon dioxide and wastes. Of course future development of bioprinting can also potentially overcome vascularization challenge. However, In vivo, capillaries are found within a distance of 100 mm from most cells so that there is sufficient diffusion for the cells to survive. For distances more than that, such as thick tissues in printed organs, additional means for diffusion may be needed.Also, the bioprinting process is not currently highly automated and plenty of manual operations at a spread of steps may result in slow processing speeds and increase the prospect for mistakes and errors. To form a highly mimetic tissue or organ on a macro scale, bioprinted cells should proliferate. When selecting cells, two main factors are considered: how bioprinted cells can imitate the physiological state of cells in vivo and how much bioprinted cells can perform their in vivo function under optimized microenvironments. Artificial tissues are seeded by either printing functional primary cells with supporting cells or printing progenitors or stem cells for further differentiation. Direct printing of primary cells can rapidly increase the complexness of bioprinting

نویسندگان

Nima Beheshtizadeh

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Iran

Maryam Sharifi Sistani

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Iran

Mahshid Saleh

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Iran